Blood Coagulation Disorders in Hemophilia

Blood coagulation in hemophilia A and hemophilia C.

Tissue factor (TF)-induced coagulation was compared in contact pathway suppressed human blood from normal, factor VIII-deficient, and factor XI-deficient donors. The progress of the reaction was analyzed in quenched samples by immunoassay and immunoblotting for fibrinopeptide A (FPA), thrombin-antithrombin (TAT), factor V activation, and osteonectin. In hemophilia A blood (factor VIII:C <1%) tr...

Mechanism of factor VIIa-dependent coagulation in hemophilia blood.

The ability of factor VIIa to initiate thrombin generation and clot formation in blood from healthy donors, blood from patients with hemophilia A, and in anti-factor IX antibody-induced ("acquired") hemophilia B blood was investigated. In normal blood, both factor VIIa-tissue factor (TF) complex and factor VIIa alone initiated thrombin generation. The efficiency of factor VIIa was about 0.0001 ...

Disorders of the blood coagulation-fibrinolytic system

Most human cells have no direct contact with the external environment and their living conditions are ensured by blood. An essential criterion for normal blood circulation is the ability of the blood to arrest bleeding at sites of tissue injury and to prevent thrombus formation inside the blood vessels under normal conditions. The balance between these two extreme states is rigorously controlle...

[Disseminated intravasal blood coagulation disorders following injuries].

CLINICAL CONFERENCE Disorders of Coagulation of Blood

155 PEDIATRICS, January 1958 DR. SCHULMAN: The case we would like to discuss is one chosen for its own intrinsic interest, and also because it provides a good opportunity to illustrate some of our newer know!edge of coagulation in general, and hemophilia in particular. The patient is a 4-year-old boy who was referred to this hospital for investigation of a hemorrhagic diathesis. His birth was n...